Antidiabetic activity of aqueous stem bark extract of Annickia polycarpa in alloxan-induced diabetic mice
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Traditional and Complementary Medicine
Abstract
Background and aim: There is a growing need to develop new drugs for type II diabetes mellitus (DM)
from plant sources due to the high cost and adverse side effects of current drug therapies. To this end, the
antidiabetic activity of aqueous stem-bark extract of A. polycarpa (APE) in alloxan-induced diabetic ICR
mice was investigated.
Experimental procedure: The effect of APE (20, 100 and 500 mg/kg), glibenclamide and metformin as
positive controls, were determined over 4 weeks on fasting blood glucose (FBG). An oral glucose tolerance
test (OGTT) was also conducted. The effects of these treatments on the morphology of the pancreas
were assessed. In addition, phytochemical constituents and antioxidant properties of APE were
determined.
Results and conclusion: APE, like glibenclamide and metformin, showed significant hypoglycaemic effect.
The OGTT supported the hypoglycaemic effect. The destroyed pancreatic beta-cells in diabetic control
mice were restored to normal by APE or drug treatment. APE showed antioxidant activity by scavenging
DPPH free radicals; this may be due to the presence of phenolic compounds, particularly flavonoids.
Thus, APE may act by restoring pancreatic beta-cell integrity through mopping of reactive oxygen species
(ROS) associated with the diabetic state, and thereby improving pancreatic function and consequently,
the lowering of FBG levels. These findings provide ample evidence to validate the traditional use of
A. polycarpa in the management of DM.
© 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier
Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/
licenses/by-nc-nd/4.0/).
Description
Research Article
Keywords
A. polycarpa, Alloxan, Diabetes, Antioxidant, Hypoglycaemia