Clinical significance of thiopentone binding to haemoglobin and plasma protein

Thumbnail Image

Date

1973-08

Journal Title

Journal ISSN

Volume Title

Publisher

British Journal of Anaesthesia

Abstract

The minimum dose of thiopentone required to induce anaesthesia was determined bygiving thiopentone incrementally until verbal counting and eyelash reflexes wereabolished. Males required 2.75 mg/kg (±0.11 SE) and females 2.16 mg/kg ( + 0.10 SE)to abolish verbal counting. Thiopentone requirement correlated positively with haemo-globin concentration (P<0.001) but not with plasma albumin, Ol globulin, total globulinor A/G ratio. The presence of sickle-cell haemoglobins did not influence thiopentonerequirements. It is suggested that this result may have clinical importance

Description

Keywords

Citation

Endorsement

Review

Supplemented By

Referenced By