Invasive disease and paediatric carriage of streptococcus pneumoniae in Ghana
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Date
2010
Authors
Donkor, E.S.
Newman, M.J.
Oliver-Commey, J.
Bannerman, E.
Dayie, N.T.K.D.
Badoe, E.V.
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Abstract
This study was carried out primarily to evaluate the public health burden related to Streptococcus pneumoniae in Ghana and to provide related preliminary molecular epidemiological data on the organism. Invasive and nasopharyngeal specimens were screened for S. pneumoniae, and isolates were subjected to serotyping, multilocus sequence typing (MLST) and antibiotic susceptibility testing. Overall, the prevalence of S. pneumoniae in cerebrospinal fluid (CSF) was 1.7%, in blood was 0.2%, and in nasopharyngeal specimens was 15.3%. The prevalence of multiple drug resistance among the isolates was 48.6%, while the percentage resistance to various drugs was in the range of 11.184.0%. Serotyping of the S. pneumoniae isolates showed 7 different serotypes (3, 6B, 9, 10, 14, 16 and 23F). The extent of coverage of serotypes by the 7-valent pneumococcal conjugate vaccine was 57.1%, for the 10-valent vaccine was 57.1%, and for the 13-valent vaccine was 71.4%. MLST of 7 housekeeping genes of the organism showed a high level of genetic diversity among the isolates. S. pneumoniae appears to be an important organism in invasive infections in Ghana, being the most prevalent organism in CSF in this study. The high multiple drug resistance of the organism observed heightens the public health burden, which may be controlled by pneumococcal conjugate vaccines to a large extent. © 2010 Informa UK Ltd.
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Keywords
EMTREE drug terms: ampicillin; cefotaxime; cefuroxime; chloramphenicol; ciprofloxacin; cloxacillin; cotrimoxazole; erythromycin; gentamicin; penicillin G; Pneumococcus vaccine EMTREE medical terms: adolescent; adult; aged; alpha hemolytic Streptococcus; antibiotic sensitivity; article; bacterium isolate; blood; cerebrospinal fluid; child; Chryseobacterium meningosepticum; Cryptococcus neoformans; Escherichia coli; genetic variability; Ghana; Haemophilus influenzae; housekeeping gene; human; infant; major clinical study; multidrug resistance; multilocus sequence typing; nasopharynx; Neisseria meningitidis; nonhuman; preschool child; Proteus; Pseudomonas aeruginosa; public health; Salmonella; school child; serotyping; Staphylococcus aureus; Streptococcus pneumoniae; subspecies MeSH: Adolescent; Adult; Aged; Bacterial Typing Techniques; Carrier State; Cerebrospinal Fluid; Child; Child, Preschool; DNA Fingerprinting; Drug Resistance, Multiple, Bacterial; Ghana; Humans; Infant; Infant, Newborn; Microbial Sensitivity Tests; Middle Aged; Nasopharynx; Pneumococcal Infections; Pneumococcal Vaccines; Prevalence; Sequence Analysis, DNA; Serotyping; Streptococcus pneumoniae; Young Adult Medline is the source for the MeSH terms of this document.
Citation
Donkor, E. S., Newman, M. J., Oliver-Commey, J., Bannerman, E., Dayie, N. T. K. D., & Badoe, E. V. (2010). Invasive disease and paediatric carriage of streptococcus pneumoniae in Ghana. Scandinavian Journal of Infectious Diseases, 42(4), 254-259