Occurrence of transmitted HIV-1 drug resistance among Drug-naïve pregnant women in selected HIV-care centres in Ghana
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Date
2017-03
Journal Title
Journal ISSN
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Publisher
Ghana Medical Journal
Abstract
Background: Access to antiretroviral therapy in Ghana has been scaled up across the country over the last decade
.This study sought to determine the occurrence of transmitted HIV-1 drug resistance in pregnant HIV-1 positive
women yet to initiate antiretroviral therapy at selected HIV Care Centres in Ghana.
Methods: Plasma specimens from twenty-six (26) HIV seropositive pregnant women who were less than 28weeks
pregnant with their first pregnancy and ART naïve were collected from selected HIV care centres in three (3) regions
in Ghana. Genotypic testing was done for the reverse transcriptase gene and the sequences generated were
analyzed for HIV-1 drug resistance mutations using the Stanford University HIV Drug Resistance Database.
Results: Resistance mutations associated with the reverse transcriptase gene were detected in 4 (15.4%) of the participants.
At least one major drug resistance mutation in the reverse transcriptase gene was found in 3 (11.5%) of the
women.
Conclusion: The detection of transmitted HIV-1 drug resistance in this drug-naïve group in two regional HIV care
sites is an indication of the need for renewed action in monitoring the emergence of transmitted HIV-1 drug resistance
in Ghana.
Description
Journal Article
Keywords
antiretroviral therapy, emergence, drug resistance, mutations