Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri
dc.contributor.author | Asare, G.A. | |
dc.contributor.author | Bugyei, K. | |
dc.contributor.author | Fiawoyi, I. | |
dc.contributor.author | Asiedu-Gyekye, I.J. | |
dc.contributor.author | Gyan, B. | |
dc.contributor.author | Adjei, S. | |
dc.contributor.author | Addo, P. | |
dc.contributor.author | Otu-Nyarko, L. | |
dc.contributor.author | Nyarko, A. | |
dc.date.accessioned | 2018-12-13T10:36:19Z | |
dc.date.available | 2018-12-13T10:36:19Z | |
dc.date.issued | 2013-04 | |
dc.description.abstract | Context: Phyllanthus niruri L. (Euphorbiaceae), a medicinal plant traditionally known for dissolving kidney stones, is used prophylactically as an antimalarial agent. Objective: The study was undertaken to determine its effect on some male hormones and other toxicological properties due to paucity of its data despite its wide use. Material and methods: Male Sprague-Dawley rats (100-140g) were used. Group 1 [control group (C), n=6] received water. Group 2 [low-dose test group (LD), n=6] received 50mg/kgbody weight (b.wt.) aqueous leaf extract orally. Group 3 [high-dose test group (HD), n=6] received 500mg/kgb.wt. extract for 90 days. Upon sacrifice, among other organs the testes were harvested. Blood samples drawn were used for biochemical (including progesterone, estrogen and testosterone), cytotoxicity and hematological assays. Results: C, LD and HD estrogen values were 192±25, 385±122 and 962±357pg/ml, respectively. In the same order, progesterone values were 96±24, 155±45 and 320±80pg/ml, respectively. Testosterone levels were 5210±1090, 4710±220 and 4500±580pg/ml, respectively. Significant differences were observed in the estrogen and progesterone levels (p=0.001). Degenerative changes were observed histologically. Cytotoxicity at 50% (CC50) was 10.0g/ml. Discussion and conclusion: This antimalarial plant is mildly cytotoxic with male antifertility properties. © 2013 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. | en_US |
dc.identifier.other | DOI: 10.3109/13880209.2013.764325 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/26392 | |
dc.language.iso | en | en_US |
dc.publisher | Pharmaceutical Biology | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Medicinal plant | en_US |
dc.subject | Progesterone | en_US |
dc.subject | Testosterone | en_US |
dc.title | Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri | en_US |
dc.type | Article | en_US |
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