Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

dc.contributor.authorMinas, T.Z.
dc.contributor.authorTettey, Y.
dc.contributor.authorBiritwum, R.B.
dc.date.accessioned2023-08-24T17:47:55Z
dc.date.available2023-08-24T17:47:55Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstracthe association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from Ghana and the United States, using CLIA-certified mass spectrometry-based assays. We investigate their associations with population groups (Ghanaian, African American, European American men), lifestyle fac tors, the fatty acid desaturase (FADS) genetic locus, and prostate cancer. Blood levels of circulating fatty acids vary significantly between the three population groups, particularly trans, omega-3 and omega-6 fatty acids. FADS1/2 germline genetic variants and lifestyle factors explain some of the variation in fatty acid levels, with the FADS1/2 locus showing population-specific associations, sug gesting differences in their control by germline genetic factors. All trans fatty acids, namely elaidic, palmitelaidic, and linoelaidic acids, associated with an increase in the odds of developing prostate cancer, independent of ancestry, geographic location, or potential confounders.en_US
dc.identifier.otherhttps://doi.org/10.1038/s41467-023-39865-9
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39839
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.subjectprostate canceren_US
dc.subjecttrans fatty aciden_US
dc.subjectAmerican menen_US
dc.subjectGhanaian menen_US
dc.titleCirculating trans fatty acids are associated with prostate cancer in Ghanaian and American menen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Circulating-trans-fatty-acids-are-associated-with-prostate-cancer-in-Ghanaian-and-American-menNature-Communications.pdf
Size:
1.58 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: