High level of colonization with third-generation cephalosporin-resistant Enterobacterales in African community settings, Ghana

dc.contributor.authorObeng-Nkrumah, N.
dc.contributor.authorOpinta, J.A.
dc.contributor.authorNewman, M.J.
dc.contributor.authoret al.
dc.date.accessioned2023-05-16T12:14:51Z
dc.date.available2023-05-16T12:14:51Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractA cross-sectional survey was conducted in eight Ghanaian communities to investigate the extent of intestinal colonization with 3rd-generation cephalosporin-resistant Enterobacterales. The study collected faecal samples and corresponding lifestyle data from 736 healthy residents to assess the occurrence of cephalosporin resistant Escherichia coli and Klebsiella pneumoniae, with a focus on genotypes of plasmid-mediated ESBLs, AmpCs, and carbapenemases. The results showed that 371 participants (50.4%) carried 3rd-generation cephalosporin-resistant E. coli (n=362) and K. pneumoniae (n=9). Most of these were ESBL-producing E. coli (n=352, 94.9%), carrying CTX-M genes (96.0%, n=338/352), mostly for CTX-M-15 (98.9%, n=334/338). Nine participants (1.2%) carried AmpC-producing E. coli that harboured blaDHA-1 or blaCMY-2 genes, and two participants (0.3%) each carried a carbapenem-resistant E. coli that harboured both blaNDM-1 and blaCMY-2. Quinolone resistant O25b: ST131 E. coli were recovered from six participants (0.8%) and were all CTX-M-15 ESBL-producers. Having a household toilet facility was significantly associated with a reduced risk of intestinal colonization (adjusted odds ratio, 0.71; 95% CI, 0.48-0.99; P-value=0.0095) in multivariate analysis. These findings raise serious public health concerns, and effective control of the spread of antibiotic-resistant bacteria is possible by providing better sanitary conditions for communities.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.diagmicrobio.2023.115918
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39058
dc.language.isoenen_US
dc.publisherDiagnostic Microbiology and Infectious Diseaseen_US
dc.subjectFecal carriageen_US
dc.subjectRisk factorsen_US
dc.subjectAmpCsen_US
dc.titleHigh level of colonization with third-generation cephalosporin-resistant Enterobacterales in African community settings, Ghanaen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
High level of colonization with third-generation cephalosporin-resistant.pdf
Size:
1.16 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: