Effect of Qhloroquine on the Induction of Rat Uterine Peroxidase by an Oral Contraceptive

Thumbnail Image

Date

1979-12

Journal Title

Journal ISSN

Volume Title

Publisher

University of Ghana

Abstract

Uterine peroxidase has been induced in immature female rate with estradiol and anovlar 21. Anovlar 21 is a steroid contraceptive containing 4 mg. norethisterone acetate (a progestin) , and 0.OS mg. ethinyl estradiol (an estrogen) per tablet. Maximum enzyme aettpity was found to occur 24 hours a fter oral adminis tration o f the contraceptive. The increased peroxidase activity caused by the cotrbined steroids was inhibited by the administration o f cyclohexirrrLde and puromycin (inhibitors o f protein biosgitheais). Peroxidase is thus synthesised ok novo on the influence o f the steroids. Chloroquine diphosphate has also been found to increase the activity o f peroxidase, with the maximum activity occtoMng 18 hours after the drug has been injected intramuscularly. Cycloheximide has been found to prevent this stimulatory effect o f chloroquine. Chloroquine was effective in increasing peroxidase activity in vivo over a dose range o f 0-20 mg/kg. body weight. I t however± did not affect peroxidase activity in vitro. Chloroquine potentiated uterine peroxidase induction by anovlar 21. Chloroquine and/or anovlar 21 prevented the production o f litte r by adult female rats.

Description

Thesis(M.Phil)-University of Ghana, 1979

Keywords

Citation

Endorsement

Review

Supplemented By

Referenced By