Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases

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dc.contributor.authorHelegbe, C.K.
dc.contributor.authorWemakor, A.
dc.contributor.authorAmeade, E.P.K.
dc.contributor.authorAnabire, N.G.
dc.contributor.authorAnaba, F.
dc.contributor.authorBautista, J.M.
dc.contributor.authorZorn, B.G.
dc.date.accessioned2023-09-12T11:38:03Z
dc.date.available2023-09-12T11:38:03Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractDuring pregnancy, women have an increased relative risk of exposure to infectious diseases. This study was designed to assess the prevalence of the co-occurrence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) and sickle cell trait (SCT) and the impact on anemia outcomes among pregnant women exposed to frequent infectious diseases. Over a six-year period (March 2013 to October 2019), 8473 pregnant women attending antenatal clinics (ANCs) at major referral hospitals in Northern Ghana were recruited and diagnosed for common infectious diseases (malaria, syphilis, hepatitis B, and HIV), G6PDd, and SCT. The prevalence of all the infections and anemia did not differ between women with and without G6PDd (χ 2 < 3.6, p > 0.05 for all comparisons). Regression analysis revealed a significantly higher proportion of SCT in pregnant women with G6PDd than those without G6PDd (AOR = 1.58; p < 0.011). The interaction between malaria and SCT was observed to be associated with anemia outcomes among the G6PDd women (F-statistic = 10.9, p < 0.001). Our findings show that anemia is a common condition among G6PDd women attending ANCs in northern Ghana, and its outcome is impacted by malaria and SCT. This warrants further studies to understand the impact of antimalarial treatment and the blood transfusion outcomes in G6PDd/SCT pregnant women.en_US
dc.identifier.citationCitation: Helegbe, G.K.; Wemakor, A.; Ameade, E.P.K.; Anabire, N.G.; Anaba, F.; Bautista, J.M.; Zorn, B.G. Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases. J. Clin. Med. 2023, 12, 5085. https:// doi.org/10.3390/jcm12155085en_US
dc.identifier.otherhttps://doi.org/10.3390/jcm12155085
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39962
dc.language.isoenen_US
dc.publisherJournal of Clinical Medicineen_US
dc.subjectpregnant womenen_US
dc.subjectantenatal careen_US
dc.subjectanemiaen_US
dc.subjectG6PD deficiencyen_US
dc.subjectsickle cell traiten_US
dc.subjecthepatitis Ben_US
dc.titleCo-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseasesen_US
dc.typeArticleen_US

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