Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Clinical Medicine
Abstract
During pregnancy, women have an increased relative risk of exposure to infectious diseases.
This study was designed to assess the prevalence of the co-occurrence of glucose-6-phosphate
dehydrogenase deficiency (G6PDd) and sickle cell trait (SCT) and the impact on anemia outcomes
among pregnant women exposed to frequent infectious diseases. Over a six-year period (March 2013
to October 2019), 8473 pregnant women attending antenatal clinics (ANCs) at major referral hospitals
in Northern Ghana were recruited and diagnosed for common infectious diseases (malaria, syphilis,
hepatitis B, and HIV), G6PDd, and SCT. The prevalence of all the infections and anemia did not
differ between women with and without G6PDd (χ
2 < 3.6, p > 0.05 for all comparisons). Regression
analysis revealed a significantly higher proportion of SCT in pregnant women with G6PDd than those
without G6PDd (AOR = 1.58; p < 0.011). The interaction between malaria and SCT was observed
to be associated with anemia outcomes among the G6PDd women (F-statistic = 10.9, p < 0.001).
Our findings show that anemia is a common condition among G6PDd women attending ANCs in
northern Ghana, and its outcome is impacted by malaria and SCT. This warrants further studies to
understand the impact of antimalarial treatment and the blood transfusion outcomes in G6PDd/SCT
pregnant women.
Description
Research Article
Keywords
pregnant women, antenatal care, anemia, G6PD deficiency, sickle cell trait, hepatitis B
Citation
Citation: Helegbe, G.K.; Wemakor, A.; Ameade, E.P.K.; Anabire, N.G.; Anaba, F.; Bautista, J.M.; Zorn, B.G. Co-Occurrence of G6PD Deficiency and SCT among Pregnant Women Exposed to Infectious Diseases. J. Clin. Med. 2023, 12, 5085. https:// doi.org/10.3390/jcm12155085