Department of Physiology

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    A Comparative Study of Isradipine and Nifedipine in the Monotherapy of Mild to Moderate Hypertension in the Ghanaian.
    (Ghana Medical Journal, 1994) Adukwei Hesse, I.F.; Addy, J.H.; Acheampong, I.W.; Wood, I.G.A.
    Clinical experience with the new dihydropyridine calcium antagonist. isradipine. is reported. Isradipine was compared with nifedipine in a multicentre open. parallel group. clinical therapeutic trial involving 70 patients with mild to moderate hypertension. A four week placebo washout period was followed by a 12 week active treatment period during which patients were randomized to receive cither 2.5 mg isradipine twice daily (n = 40) or 10 mg nifedipine three times daily ( n=30). Isradipine significantly reduced sitting systolic /diastolic blood pressures from 176.7 ± 21.0/l06.7±7.0mmHg to l42.9± 15/93.1±7.7mmHg (p< 0.001) at the end of 12 weeks. Similarly. nifedipine reduced sitting systolic/diastolic blood pressures from 170.2±1 9.5/1 06.2±7.4mmHg to 139. 1±9.7/92. 1±7.8 mmHg (p< 0.001). Normalisation (diastolic<90 mmHg) rates were 67% and 60% for isradipine and nifedipine respectively while good response (diastolic fall > 10mmHg) rate was over 85% on cither drug. Heart rate did not significantly change with either treatment. Three (3) patients taking isradipine experienced headache and 7 patients taking nifedipine had drug related adverse effects (5 had headache. I insomnia and I first dose hypotension). Therapy was Withdrawn in 4 patients taking nifedipine and 1 taking isradipine. It is concluded that isradipine is comparable to nifedipine and is an effective and well-tolerated antihypertensive agent In the Ghanaian.