Browsing by Author "Wong, S.H."
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Item Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.(2010-09) Thye, T.; Vannberg, F.O.; Wong, S.H.; Owusu-Dabo, E.; Osei, I.; Gyapong, J.; Sirugo, G.; Sisay-Joof, F.; Enimil, A.; Chinbuah, M.A.; Floyd, S.; Warndorff, D.K.; Sichali, L.; Malema, S.; Crampin, A.C.; Ngwira, B.; Teo, Y.Y.; Small, K.; Rockett, K.; Kwiatkowski, D.; Fine, P.E.; Hill, P.C.; Newport, M.; Lienhardt, C.; Adegbola, R.A.; Corrah, T.; Ziegler, A.; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, A.P.; Meyer, C.G.; Horstmann, R.D.; Hill, A.V.We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.