Browsing by Author "Sahiratmadja, E."
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Item Common variants at 11p13 are associated with susceptibility to tuberculosis(Nature Genetics, 2012) Thye, T.; Owusu-Dabo, E.; Vannberg, F.O.; van Crevel, R.; Curtis, J.; Sahiratmadja, E.; Balabanova, Y.; Ehmen, C.; Muntau, B.; Ruge, G.; Sievertsen, J.; Gyapong, J.; Nikolayevskyy, V.; Hill, P.C.; Sirugo, G.; Drobniewski, F.; van de Vosse, E.; Newport, M.; Alisjahbana, B.; Nejentsev, S.; Ottenhoff, T.H.; Hill, A.V.; Horstmann, R.D.; Meyer, C.G.After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10−9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10−11.