Browsing by Author "Gellin, B.G."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future(Vaccine, 2021) Moore, K.A.; Ostrowsky, J.T.; Kraigsley, A.M.; Mehr, A.J.; Bresee, J.S.; Friede, M.H.; Gellin, B.G.; Golding, J.P.; Hart, P.J.; Moen, A.; Weller, C.L.; Osterholm, M.T.; Ampofo, W.; Barclay, W.; Cavaleri, M.; Cohen, C.; Cowling, B.; Cox, R.; Gust, J.; Innis, B.; Kang, G.; Katz, J.; Krammer, F.; Pitisuttithum, P.; Post, D.; Rudenko, L.; Siqueira, M.; Weir, J.Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to ensure a rapid and effective public-health response to future influenza pandemics. The Influenza Vaccines Research and Development (R&D) Roadmap (IVR) was created, through an extensive international stakeholder engagement process, to promote influenza vaccine R&D. The roadmap covers a 10- year timeframe and is organized into six sections: virology; immunology; vaccinology for seasonal influenza vaccines; vaccinology for universal influenza vaccines; animal and human influenza virus infection models; and policy, finance, and regulation. Each section identifies barriers, gaps, strategic goals, milestones, and additional R&D priorities germane to that area. The roadmap includes 113 specific R&D Abbreviations: ABS, Access and Benefit Sharing; ACT, Access to COVID-19 Tools; ADCC, antibody-dependent cellular cytotoxicity; CARB-X, biopharmaceutical accelerator for combating antibiotic resistant bacteria; CEPI, Coalition for Epidemic Preparedness Innovations; CIDRAP, Center for Infectious Disease Research and Policy; CIVICs, Collaborative Influenza Vaccine Innovation Centers; COBRA, computationally optimized broadly reactive antigen; CHIVIM, controlled human influenza virus infection model; EU, European Union; FVVA, full value of vaccine assessment; GISRS, Global Influenza Surveillance and Response System; HAI, hemagglutination-inhibition; HA, hemagglutinin; HVAC, heating, ventilation, and air conditioning; IIV, inactivated influenza vaccines; IVR, Influenza Vaccines Research and Development (R&D) Roadmap; LAIV, live-attenuated influenza vaccines; LMICs, low- and middle-income countries; ME&A, monitoring, evaluation, and adjustment; NA, neuraminidase; NIAID, US National Institute of Allergy and Infectious Diseases; R&D, Research and Development; SME, subject matter expert; WHO, World Health Organization.Item Seasonal and pandemic influenza vaccine: Demand, supply and vaccine availability(Vaccine, 2014-11) Gellin, B.G.; Ampofo, W.K.nfluenza has long been a compelling example of a global pandemic threat, but the annual disease burden has been relatively underappreciated, leading to missed opportu- nities for disease reduction and prevention. Convincing evidence of seasonal burden of disease in more settings and for a wider array of influenza outcomes will be the foundation of arguments for strengthening programs to control annual influenza and to reduce the threat of future pandemics (41,42). Countries with burden of disease estimates that have agreed to share data for the global estimate of influenza mortality and influenza-associated hospitalizations, as of April 2017: blue, morbidity estimates; brown, mortality estimates; green, morbidity and mortality estimates; white, data not available. ...