A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Vaccine
Abstract
Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to
ensure a rapid and effective public-health response to future influenza pandemics. The Influenza
Vaccines Research and Development (R&D) Roadmap (IVR) was created, through an extensive international
stakeholder engagement process, to promote influenza vaccine R&D. The roadmap covers a 10-
year timeframe and is organized into six sections: virology; immunology; vaccinology for seasonal influenza
vaccines; vaccinology for universal influenza vaccines; animal and human influenza virus infection
models; and policy, finance, and regulation. Each section identifies barriers, gaps, strategic goals, milestones,
and additional R&D priorities germane to that area. The roadmap includes 113 specific R&D Abbreviations: ABS, Access and Benefit Sharing; ACT, Access to COVID-19 Tools; ADCC, antibody-dependent cellular cytotoxicity; CARB-X, biopharmaceutical accelerator
for combating antibiotic resistant bacteria; CEPI, Coalition for Epidemic Preparedness Innovations; CIDRAP, Center for Infectious Disease Research and Policy; CIVICs,
Collaborative Influenza Vaccine Innovation Centers; COBRA, computationally optimized broadly reactive antigen; CHIVIM, controlled human influenza virus infection model;
EU, European Union; FVVA, full value of vaccine assessment; GISRS, Global Influenza Surveillance and Response System; HAI, hemagglutination-inhibition; HA,
hemagglutinin; HVAC, heating, ventilation, and air conditioning; IIV, inactivated influenza vaccines; IVR, Influenza Vaccines Research and Development (R&D) Roadmap;
LAIV, live-attenuated influenza vaccines; LMICs, low- and middle-income countries; ME&A, monitoring, evaluation, and adjustment; NA, neuraminidase; NIAID, US National
Institute of Allergy and Infectious Diseases; R&D, Research and Development; SME, subject matter expert; WHO, World Health Organization.
Description
Research Article
Keywords
Influenza, Pandemic preparedness