Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa

dc.contributor.authorSarfo, F.S.
dc.contributor.authorAkinyemi, J.
dc.contributor.authorAkpalu, A.
dc.contributor.authorWahab, K.
dc.contributor.authorYaria, J.
dc.contributor.authorAdebayo, O.
dc.contributor.authorKomolafe, M.
dc.contributor.authorObiako, R.
dc.contributor.authorOwolabi, L.
dc.contributor.authorOsaigbovo, G.O.
dc.contributor.authorJenkins, C.
dc.contributor.authorMensah, Y.
dc.contributor.authorOgbole, G.
dc.contributor.authorCalys-Tagoe, B.
dc.contributor.authorAdebayo, A.
dc.contributor.authorAppiah, L.
dc.contributor.authorSingh, A.
dc.contributor.authorFakunle, A.
dc.contributor.authorUvere, E.
dc.contributor.authorHemant, T.
dc.contributor.authorBalogun, O.
dc.contributor.authorAdeleye, O.
dc.contributor.authorFawale, F.
dc.contributor.authorAbdulwasiu, A.
dc.contributor.authorOgunjimi, L.
dc.contributor.authorAkinola, O.
dc.contributor.authorArulogun, O.
dc.contributor.authorDonna, A.
dc.contributor.authorOgah, O.
dc.contributor.authorAkinyemi, R.
dc.contributor.authorOvbiagele, B.
dc.contributor.authorOwolabi, M.O.
dc.date.accessioned2021-09-09T16:06:01Z
dc.date.available2021-09-09T16:06:01Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractBackground: Post-stroke seizures (PSS) are associated with significant morbidity and mortality across the globe. There is a paucity of data on PSS in Africa. Purpose: To assess the frequency and factors associated with PSS by stroke types across 15 hospitals in Nigeria and Ghana. Methods: We analyzed data on all stroke cases recruited into the Stroke Investigative Research and Educational Network (SIREN). We included adults aged ≥18 years with radiologically confirmed ischemic stroke (IS) or intracerebral hemorrhage (ICH). PSS were defined as acute symptomatic seizures occurring at stroke onset and/ or during acute hospitalization up until discharge. We used logistic regression to estimate adjusted odds ratios (aOR) with 95% Confidence Interval. Results: Among 3344 stroke patients, 499 (14.9%) had PSS (95% CI: 13.7–16.2%). The mean duration of admission in days for those with PSS vs no PSS was 17.4 ± 28.6 vs 15.9 ± 24.7, p = 0.72. There were 294(14.1%) PSS among 2091 ischemic strokes and 159(17.7%) among 897 with ICH, p = 0.01. The factors associated with PSS occurrence were age < 50 years, aOR of 1.59 (1.08–2.33), National Institute of Health Stroke Score (NIHSS), 1.29 (1.16–1.42) for each 5 units rise and white cell count 1.07 (1.01–1.13) for each 10^3 mm3 rise. Factors associated with PSS in ischemic were NIHSS score, aOR of 1.17 (1.04–1.31) and infarct volume of 10–30 cm3 aOR of 2.17(1.37–3.45). Among ICH, associated factors were alcohol use 5.91 (2.11–16.55) and lobar bleeds 2.22 (1.03–4.82). Conclusion: The burden of PSS among this sample of west Africans is substantial and may contribute to poor outcomes of stroke in this region. Further longitudinal studies are required to understand the impact on morbidity and mortality arising from PSS in Africa.en_US
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/36713
dc.language.isoenen_US
dc.publisherJournal of the Neurological Sciencesen_US
dc.subjectSeizuresen_US
dc.subjectEpilepsyen_US
dc.subjectStroke typesen_US
dc.subjectAfricaen_US
dc.titleFrequency and factors associated with post-stroke seizures in a large multicenter study in West Africaen_US
dc.typeArticleen_US

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