Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes

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dc.contributor.authorUsui, M.
dc.contributor.authorPrajapati, S.K.
dc.contributor.authorAyanful-Torgby, R.
dc.contributor.authorAcquah, F.K.
dc.contributor.authorCudjoe, E.
dc.contributor.authorKakaney, C.
dc.contributor.authorAmponsah, J.A.
dc.contributor.authorObboh, E.K.
dc.contributor.authorReddy, D.K.
dc.contributor.authorBarbeau, M.C.
dc.contributor.authorSimons, L.M.
dc.contributor.authorCzesny, B.
dc.contributor.authorRaiciulescu, S.
dc.contributor.authorOlsen, C.
dc.contributor.authorAbuaku, B.K.
dc.contributor.authorAmoah, L.E.
dc.contributor.authorWilliamson, K.C.
dc.date.accessioned2019-08-19T16:19:29Z
dc.date.available2019-08-19T16:19:29Z
dc.date.issued2019
dc.description.abstractPlasmodium sexual differentiation is required for malaria transmission, yet much remains unknown about its regulation. Here, we quantify early gametocyte-committed ring (gc-ring) stage, P. falciparum parasites in 260 uncomplicated malaria patient blood samples 10 days before maturation to transmissible stage V gametocytes using a gametocyte conversion assay (GCA). Seventy six percent of the samples have gc-rings, but the ratio of gametocyte to asexual-committed rings (GCR) varies widely (0–78%). GCR correlates positively with parasitemia and is negatively influenced by fever, not hematocrit, age or leukocyte counts. Higher expression levels of GDV1-dependent genes, ap2-g, msrp1 and gexp5, as well as a gdv1 allele encoding H217 are associated with high GCR, while high plasma lysophosphatidylcholine levels are associated with low GCR in the second study year. The results provide a view of sexual differentiation in the field and suggest key regulatory roles for clinical factors and gdv1 in gametocytogenesis in vivo. © 2019, The Author(s).en_US
dc.identifier.othervol.10:2140
dc.identifier.other10.1038/s41467-019-10172-6
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32032
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.titlePlasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genesen_US
dc.typeArticleen_US

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