Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana.
| dc.contributor.author | Oduro, A.R. | |
| dc.contributor.author | Koram, K.A. | |
| dc.contributor.author | Rogers, W. | |
| dc.contributor.author | Atuguba, F. | |
| dc.contributor.author | Ansah, P. | |
| dc.contributor.author | Anyorigiya, T. | |
| dc.contributor.author | Ansah, A. | |
| dc.contributor.author | Anto, F. | |
| dc.contributor.author | Mensah, N. | |
| dc.contributor.author | Hodgson, A. | |
| dc.contributor.author | Nkrumah, F. | |
| dc.date.accessioned | 2013-06-27T10:37:21Z | |
| dc.date.accessioned | 2017-10-16T13:03:52Z | |
| dc.date.available | 2013-06-27T10:37:21Z | |
| dc.date.available | 2017-10-16T13:03:52Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Study design. Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6-59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition for severe malaria. Results. Of the total children screened, 45.2% (868/1921) satisfied the criteria for severe malaria. Estimated incidence of severe malaria was 3.4% (range: 0.4-8.3%) cases per year. The disease incidence was seasonal: 560 cases per year, of which 70.4% occurred during the wet season (June-October). The main manifestations were severe anaemia (36.5%); prolonged or multiple convulsions (21.6%); respiratory distress (24.4%) and cerebral malaria (5.4%). Others were hyperpyrexia (11.1%); hyperparasitaemia (18.5%); hyperlactaemia (33.4%); and hypoglycaemia (3.2%). The frequency of severe anaemia was 39.8% in children of six to 24 months of age and 25.9% in children of 25-60 months of age. More children (8.7%) in the 25-60 months age group had cerebral malaria compared with 4.4% in the 6-24 months age group. The overall case fatality ratio was 3.5%. Cerebral malaria and hyperlactataemia were the significant risk factors associated with death. Severe anaemia, though a major presentation, was not significantly associated with risk of death. Conclusion. Severe malaria is a frequent and seasonal childhood disease in northern Ghana and maybe an adequate endpoint for future malaria vaccine trials. © 2007 Oduro et al; licensee BioMed Central Ltd. | en_US |
| dc.identifier.citation | Oduro, A. R., Koram, K. A., Rogers, W., Atuguba, F., Ansah, P., Anyorigiya, T., . . . Nkrumah, F. (2007). Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana. Malaria Journal, 6. | en_US |
| dc.identifier.issn | 14752875 | |
| dc.identifier.uri | http://197.255.68.203/handle/123456789/4245 | |
| dc.language.iso | en | en_US |
| dc.subject | EMTREE medical terms: acute disease; age distribution; anemia; article; brain malaria; cause of death; clinical feature; comparative study; controlled study; convulsion; disease severity; fatality; female; Ghana; human; hyperlactatemia; hyperpyrexia; hypoglycemia; infant; major clinical study; malaria falciparum; male; parasitemia; preschool child; prevalence; respiratory distress; screening; seasonal variation; standard; world health organization; age; analysis of variance; anemia; animal; breathing disorder; Ghana; incidence; malaria; malaria falciparum; mortality; prognosis; risk factor; season; survival rate | en_US |
| dc.title | Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana. | en_US |
| dc.type | Article | en_US |