Rotavirus Vaccine Take in Infants Is Associated With Secretor Status

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dc.contributor.authorArmah, G.E.
dc.contributor.authorCortese, M.M.
dc.contributor.authorDennis, F.E.
dc.contributor.authorYu, Y.
dc.contributor.authorMorrow, A.L.
dc.contributor.authorMcNeal, M.M.
dc.contributor.authorLewis, K.D.C.
dc.contributor.authorAwuni, D.A.
dc.contributor.authorArmachie, J.
dc.contributor.authorParashar, U.D.
dc.date.accessioned2019-05-21T11:12:34Z
dc.date.available2019-05-21T11:12:34Z
dc.date.issued2019-03
dc.description.abstractRotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion (‘vaccine take”) among 166 Ghanaian infants after 2–3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2–8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of “take” for any particular rotavirus vaccine may differ across populations based on HBGAs.en_US
dc.identifier.otherhttps://doi.org/10.1093/infdis/jiy573
dc.identifier.otherVolume 219, Issue 5,Pages 746–749
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30136
dc.language.isoenen_US
dc.publisherJournal of Infectious Diseasesen_US
dc.subjectFUT2en_US
dc.subjectLewis antigenen_US
dc.subjectRotavirusen_US
dc.subjectSecretoren_US
dc.subjectVaccineen_US
dc.titleRotavirus Vaccine Take in Infants Is Associated With Secretor Statusen_US
dc.typeArticleen_US

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