Accramycin A, A New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37

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dc.contributor.authorKyeremeh, K.
dc.contributor.authorMaglangit, F.
dc.contributor.authorFang, Q.
dc.contributor.authorLeman, V.
dc.contributor.authorSoldatou, S.
dc.contributor.authorEbel, R.
dc.contributor.authorDeng, H.
dc.date.accessioned2019-09-26T13:17:13Z
dc.date.available2019-09-26T13:17:13Z
dc.date.issued2019-09-12
dc.descriptionResearch Articleen_US
dc.description.abstractAbstract: Drug-like molecules are known to contain many di erent building blocks with great potential as pharmacophores for drug discovery. The continued search for unique sca olds in our laboratory led to the isolation of a novel Ghanaian soil bacterium, Streptomyces sp. MA37. This strain produces many bioactive molecules, most of which belong to carbazoles, pyrrolizidines, and fluorinated metabolites. Further probing of the metabolites of MA37 has led to the discovery of a new naphthacene-type aromatic natural product, which wehave named accramycinA1. This molecule was isolated using an HPLC-photodiode array (PDA) guided isolation process and MS/MS molecular networking. The structure of 1 was characterized by detailed analysis of LC-MS, UV, 1D, and 2D NMR data. Preliminary studies on the antibacterial properties of 1 using Group B Streptococcus (GBS) produced a minimum inhibitory concentration (MIC) of 27 g/mL. This represents the first report of such bioactivity amongst the naphthacene-type aromatic polyketides, and also suggests the possibility for the further development of potent molecules against GBS based on the accramycin sca old. A putative acc biosynthetic pathway for accramycin, featuring a tridecaketide-specific type II polyketide synthase, was proposed.en_US
dc.description.sponsorshipUniversity of the Philippines,Leverhulme Trust-Royal,MRC African Research Leaders Award British Council/Newton Fund for financial support through the Institutional Links scheme (Project ,University of Aberdeen Elphinstone Scholarship and Scottish Funding Council/ScotCHEM for financial support through the PEER/PERCE Funding.en_US
dc.identifier.otherdoi:10.3390/molecules24183384
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32308
dc.language.isoenen_US
dc.publishermoleculesen_US
dc.relation.ispartofseries24;18
dc.subjectAccramycinen_US
dc.subjectNaphthaceneen_US
dc.subjectType II polyketideen_US
dc.subjectStreptomyces sp.en_US
dc.subjectMA37en_US
dc.subjectGroup B Streptococcusen_US
dc.titleAccramycin A, A New Aromatic Polyketide, from the Soil Bacterium, Streptomyces sp. MA37en_US
dc.typeArticleen_US

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