An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research

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dc.contributor.authorBoatemaa, G.D.
dc.contributor.authorCampbell, A.D.
dc.contributor.authorColombatti, R.
dc.contributor.authorAndemariam, B.
dc.contributor.authorStrunk, C.
dc.contributor.authorTartaglione, I.
dc.contributor.authorPiccone, C.M.
dc.contributor.authorManwani, D.
dc.contributor.authorAsare, E.V.
dc.contributor.authorBoruchov, D.
dc.contributor.authorFarooq, F.
dc.contributor.authorUrbonya, R.
dc.contributor.authorPerrotta, S.
dc.contributor.authorSainati, L.
dc.contributor.authorRivers, A.
dc.contributor.authorRao, S.
dc.contributor.authorZempsky, W.
dc.contributor.authorSey, F.
dc.contributor.authorSegbefia, C.
dc.contributor.authorInusa, B.
dc.contributor.authorAntwi-Boasiako, C.
dc.date.accessioned2020-06-25T12:03:34Z
dc.date.available2020-06-25T12:03:34Z
dc.date.issued2020-04-16
dc.descriptionResearch Articleen_US
dc.description.abstractMillions are affected by sickle cell disease (SCD) worldwide with the greatest burden in sub-Saharan Africa. While its origin lies historically within the malaria belt, ongoing changes in migration patterns have shifted the burden of disease resulting in a global public health concern. We created the Consortium for the Advancement of Sickle Cell Research (CASiRe) to understand the different phenotypes of SCD across 4 countries (USA, UK, Italy, and Ghana). Here, we report the multi-generational ethnic and racial background of 877 SCD patients recruited in Ghana (n = 365, 41.6%), the USA (n = 254, 29%), Italy (n = 81, 9.2%), and the UK (n = 177, 20.2%). West Africa (including Benin Gulf) (N = 556, 63.4%) was the most common geographic region of origin, followed by North America (N = 184, 21%), Caribbean (N = 51, 5.8%), Europe (N = 27, 3.1%), Central Africa (N = 24, 2.7%), and West Africa (excluding Benin Gulf) (N = 21, 2.4%). SCD patients in Europe were primarily West African (73%), European (10%), Caribbean (8%), and Central African (8%). In the USA, patients were largely African American (71%), Caribbean (13%), or West African (10%). Most subjects identified themselves as Black or African American; the European cohort had the largest group of Caucasian SCD patients (8%), including 21% of the Italian patients. This is the first report of a comprehensive analysis of ethnicity within an international, transcontinental group of SCD patients. The diverse ethnic backgrounds observed in our cohort raises the possibility that genetic and environmental heterogeneity within each SCD population subgroup can affect the clinical phenotype and research outcomes.en_US
dc.identifier.citationCampbell, A.D., Colombatti, R., Andemariam, B. et al. An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research. J. Racial and Ethnic Health Disparities (2020). https://doi.org/10.1007/s40615-020-00762-2en_US
dc.identifier.otherhttps://doi.org/10.1007/s40615-020-00762-2
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/35356
dc.language.isoenen_US
dc.publisherJournal of Racial and Ethnic Health Disparitiesen_US
dc.relation.ispartofseries;2020
dc.subjectSickle cellen_US
dc.subjectRaceen_US
dc.subjectEthnicityen_US
dc.subjectPhenotypeen_US
dc.subjectInternationalen_US
dc.titleAn Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Researchen_US
dc.typeArticleen_US

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