A new dimeric imidazole alkaloid plasmid conjugation inhibitor from Lepidium sativum
| dc.contributor.author | Kwapong, A.A. | |
| dc.contributor.author | Stapleton, P. | |
| dc.contributor.author | Gibbons, S. | |
| dc.date.accessioned | 2018-09-26T15:22:56Z | |
| dc.date.available | 2018-09-26T15:22:56Z | |
| dc.date.issued | 2018-05 | |
| dc.description.abstract | Phytochemical investigation of the methanolic extract of Lepidium sativum seeds led to the isolation of a new compound, named 2-(3-(3-((1H-imidazol-2-yl)methyl)-5-methoxyphenoxy)benzyl)-1H-imidazole and given the trivial name Lepidine AK (1), along with three known compounds; Lepidine E (2), Lepidine B (3) and 2-(3-(2-((1H-imidazol-2-yl)methyl)-6-methoxyphenoxy)benzyl)-1H-imidazole (4). The structures were elucidated based on NMR spectroscopy, UV, IR and high-resolution electrospray ionization mass spectrometry. The isolated compounds were tested for bacterial conjugation inhibition. Lepidine AK (1, 100 μg/mL) reduced the conjugal transfer of the IncI2 plasmid TP114 to 44.7 ± 3.5% but interestingly promoted the conjugation of the IncN plasmid pKM101 to greater than 120%. © 2018 | en_US |
| dc.identifier.other | doi:doi.org/10.1016/j.tetlet.2018.04.028 | |
| dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/24409 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.subject | Conjugation | en_US |
| dc.subject | Dimeric | en_US |
| dc.subject | Imidazole | en_US |
| dc.subject | Lepidine | en_US |
| dc.subject | Plasmids | en_US |
| dc.title | A new dimeric imidazole alkaloid plasmid conjugation inhibitor from Lepidium sativum | en_US |
| dc.type | Article | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.6 KB
- Format:
- Item-specific license agreed upon to submission
- Description: