Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated plasmodium falciparum malaria.

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dc.contributor.authorJensen, A. T. R.
dc.contributor.authorZornig, H. D.
dc.contributor.authorBuhmann, C.
dc.contributor.authorSalanti, A.
dc.contributor.authorKoram, K. A.
dc.contributor.authorRiley, E. M.
dc.contributor.authorTheander, T.G.
dc.contributor.authorHviid, L.
dc.contributor.authorStaalsoe, T.
dc.date.accessioned2013-06-26T19:47:35Z
dc.date.accessioned2017-10-16T12:58:31Z
dc.date.available2013-06-26T19:47:35Z
dc.date.available2017-10-16T12:58:31Z
dc.date.issued2003-07
dc.description.abstractGender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.en_US
dc.identifier.citationJensen, A. T. R., Zornig, H. D., Buhmann, C., Salanti, A., Koram, K. A., Riley, E. M., . . . Staalsoe, T. (2003). Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated plasmodium falciparum malaria. Infection and Immunity, 71(7), 4193-4196.en_US
dc.identifier.issn00199567
dc.identifier.urihttp://197.255.68.203/handle/123456789/4219
dc.language.isoenen_US
dc.subjectEMTREE drug terms: chondroitin sulfate; gene product; membrane antigen EMTREE medical terms: animal cell; animal experiment; animal model; animal tissue; antibody specificity; antigen expression; antigen recognition; article; controlled study; female; gender; gene expression regulation; gene identification; gene isolation; genetic recombination; genetic selection; human; human cell; human tissue; ligand binding; malaria falciparum; male; molecular biology; mouse; nonhuman; parity; Plasmodium falciparum; pregnancy associated malaria; pregnancy complication; priority journal; protein domain; sex difference; transcription regulation; vsa geneen_US
dc.titleLack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated plasmodium falciparum malaria.en_US
dc.typeArticleen_US

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