Phylogenomics of Mycobacterium Africanum Reveals a New Lineage and a Complex Evolutionary History

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dc.contributor.authorCoscolla, M.
dc.contributor.authorGagneux, S.
dc.contributor.authorOtchere, I.D.
dc.contributor.authoret al.
dc.date.accessioned2023-06-26T09:35:43Z
dc.date.available2023-06-26T09:35:43Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractHuman tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC). The MTBC comprises several human-adapted lineages known as M. tuberculosis sensu stricto, as well as two lineages (L5 and L6) traditionally referred to as Mycobacterium africanum. Strains of L5 and L6 are largely limited to West Africa for reasons unknown, and little is known of their genomic diversity, phylogeography and evolution. Here, we analysed the genomes of 350 L5 and 320 L6 strains, isolated from patients from 21 African countries, plus 5 related genomes that had not been classified into any of the known MTBC lineages. Our population genomic and phylogeographical analyses showed that the unclassified genomes belonged to a new group that we propose to name MTBC lineage 9 (L9). While the most likely ancestral distribution of L9 was predicted to be East Africa, the most likely ancestral distribution for both L5 and L6 was the Eastern part of West Africa. Moreover, we found important differences between L5 and L6 strains with respect to their phylogeographical substructure and genetic diversity. Finally, we could not confirm the previous association of drug-resistance markers with lineage and sublineages. Instead, our results indicate that the association of drug resistance with lineage is most likely driven by sample bias or geography. In conclusion, our study sheds new light onto the genomic diversity and evolutionary history of M. africanum, and highlights the need to consider the particularities of each MTBC lineage for understanding the ecology and epidemiology of TB in Africa and globally.en_US
dc.identifier.other10.1099/mgen.0.000477
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/39374
dc.language.isoenen_US
dc.publishermicrobiology researchen_US
dc.subjectdiversityen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectmycobacteriaen_US
dc.titlePhylogenomics of Mycobacterium Africanum Reveals a New Lineage and a Complex Evolutionary Historyen_US
dc.typeArticleen_US

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