Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

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dc.contributor.authorGrau-Bove, X.
dc.contributor.authorLucas, E.
dc.contributor.authorPipini, D.
dc.contributor.authorRippon, E.
dc.contributor.authorvan ‘t Hof, A.E.
dc.contributor.authorConstant, E.
dc.contributor.authorDadzie, S.
dc.contributor.authorEgyir-Yawson, A.
dc.contributor.authorEssandoh, J.
dc.contributor.authorChabi, J.
dc.contributor.authorDjogbe´nou, L.
dc.contributor.authorHarding, N.J.
dc.contributor.authorMiles, A.
dc.contributor.authorKwiatkowski, D.
dc.contributor.authorDonnelly, M.J.
dc.contributor.authorWeetman, D.
dc.date.accessioned2021-12-29T13:35:26Z
dc.date.available2021-12-29T13:35:26Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractVector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organo phosphate pirimiphos-methyl, is essential to overcome the recurrent emergence of resis tance driven by the highly diverse Anopheles genomes. Here, we use a population genomic approach to investigate the basis of pirimiphos-methyl resistance in the major malaria vec tors Anopheles gambiae and A. coluzzii. A combination of copy number variation and a sin gle non-synonymous substitution in the acetylcholinesterase gene, Ace1, provides the key resistance diagnostic in an A. coluzzii population from Coˆte d’Ivoire that we used for sequence-based association mapping, with replication in other West African populations. The Ace1 substitution and duplications occur on a unique resistance haplotype that evolved in A. gambiae and introgressed into A. coluzzii, and is now common in West Africa primarily due to selection imposed by other organophosphate or carbamate insecticides. Our findings highlight the predictive value of this complex resistance haplotype for phenotypic resistance and clarify its evolutionary history, providing tools to for molecular surveillance of the current and future effectiveness of pirimiphos-methyl based interventions.en_US
dc.identifier.otherhttps://doi.org/10.1371/journal.pgen.1009253
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37401
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.titleResistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locusen_US
dc.typeArticleen_US

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