WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Vaccine
Abstract
While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels,
increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply
to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo
controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines
Description
Research Article
Keywords
Placebo-controlled trials, Standard of care, Standard of prevention, Trial designs, Research ethics