The COVID-19, tuberculosis and HIV/AIDS: Ménage à Trois

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dc.contributor.authorUdoakang, A.J.
dc.contributor.authorZune, A.L.D.
dc.contributor.authorTapela, K.
dc.contributor.authorNganyewo, N.N.
dc.contributor.authorOlisaka, F.N.
dc.contributor.authorAnyigba, C.A.
dc.contributor.authorTawiah-Eshun, S.
dc.contributor.authorOwusu, I.A.
dc.contributor.authorPaemka, L.
dc.contributor.authorAwandare, G.A.
dc.contributor.authorQuashie, P.K.
dc.date.accessioned2023-05-04T10:20:06Z
dc.date.available2023-05-04T10:20:06Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractIn December 2019, a novel pneumonic condition, Coronavirus disease 2019 (COVID- 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), broke out in China and spread globally. The presentation of COVID-19 is more severe in persons with underlying medical conditions such as Tuberculosis (TB), Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) and other pneumonic conditions. All three diseases are of global concern and can significantly affect the lungs with characteristic cytokine storm, immunosuppression, and respiratory failure. Co-infections of SARS-CoV-2 with HIV and Mycobacterium tuberculosis (Mtb) have been reported, which may influence their pathogenesis and disease progression. Pulmonary TB and HIV/ AIDS patients could be more susceptible to SARS-CoV-2 infection leading to lethal synergy and disease severity. Therefore, the biological and epidemiological interactions of COVID-19, HIV/AIDS, and TB need to be understood holistically. While data is needed to predict the impact of the COVID-19 pandemic on these existing diseases, it is necessary to review the implications of the evolving COVID 19 management on HIV/AIDS and TB control, including therapy and funding. Also, the impact of long COVID on patients, who may have this co-infection. Thus, this review highlights the implications of COVID-19, HIV/AIDS, and TB co-infection compares disease mechanisms, addresses growing concerns, and suggests a direction for improved diagnosis and general management.en_US
dc.identifier.otherdoi: 10.3389/fimmu.2023.1104828
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/38964
dc.language.isoenen_US
dc.publisherFrontiers in Immunologyen_US
dc.subjectCOVID-19en_US
dc.subjectHIV/AIDSen_US
dc.subjecttuberculosisen_US
dc.titleThe COVID-19, tuberculosis and HIV/AIDS: Ménage à Troisen_US
dc.typeArticleen_US

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