Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria

dc.contributor.authorQuaye, I.K.E.
dc.contributor.authorEkuban, F.A.
dc.contributor.authorGoka, B.Q.
dc.contributor.authorAdabayeri, V.
dc.contributor.authorKurtzhals, J.A.L.
dc.contributor.authorGyan, B.
dc.contributor.authorAnkrah, N.-A.
dc.contributor.authorHviid, L.
dc.contributor.authorAkanmori, B.D.
dc.date.accessioned2019-02-20T14:18:37Z
dc.date.available2019-02-20T14:18:37Z
dc.date.issued2000-03
dc.description.abstractThe haptoglobin (Hp) phenotypes were determined by polyacrylamide-gel electrophoresis in plasma samples obtained in 1997 from 113 Plasmodium falciparum malaria patients (aged 1-12 years) with strictly defined cerebral malaria, severe malarial anaemia, or uncomplicated malaria and 42 age-matched healthy controls from the same area (coastal Ghana). Hp1-1 was significantly more prevalent among the patients (43%) than among healthy controls (7.1%), whereas Hp2-1 and Hp2-2 were underrepresented among the patients (11% and 2%, respectively) compared to the control donors (33% and 14%, respectively). No significant difference in frequency of Hp0 was observed between patients and controls. Among the malaria patients, the Hp1-1 phenotype was significantly more prevalent among patients with the complications of cerebral malaria and severe anaemia compared to patients with uncomplicated disease, whereas the reverse was seen with respect to Hp2-1 and Hp2-2. Our data suggest that the Hp1-1 phenotype is associated with susceptibility to P. falciparum malaria in general, and to the development of severe disease in particular.en_US
dc.identifier.otherVol. 94(2): pp 216-9
dc.identifier.otherDOI: 10.1016/S0035-9203(00)90281-5
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/27995
dc.language.isoenen_US
dc.publisherTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.subjectGhanaen_US
dc.subjectHaptoglobinen_US
dc.subjectMalariaen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectSevere diseaseen_US
dc.subjectSusceptibilityen_US
dc.titleHaptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malariaen_US
dc.typeArticleen_US

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