Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors

dc.contributor.author	Ayerakwa, E.A.
dc.contributor.author	Abban, M.K.
dc.contributor.author	Isawumi, A.
dc.contributor.author	Mosi, L.
dc.date.accessioned	2023-05-18T15:33:29Z
dc.date.available	2023-05-18T15:33:29Z
dc.date.issued	2023
dc.description	Research Article	en_US
dc.description.abstract	Mycobacterium ulcerans is the causative agent of Buruli ulcer – a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in M. marinum, it is likely that M. ulcerans employs sporulation mechanisms for its survival and transmission. In this review, we modeled possible transmission routes and patterns of M. ulcerans from the environment to its host. We provided insights into the evolution of M. ulcerans and its genomic profiles. We discuss reservoirs of M. ulcerans as an environmental pathogen and its environmental survival. We comprehensively discuss sporulation as a possible stress response mechanism and modelled endospore formation in M. ulcerans. At last, we highlighted sporulation associated markers, which upon expression trigger endospore formation.	en_US
dc.identifier.uri	http://ugspace.ug.edu.gh:8080/handle/123456789/39098
dc.language.iso	en	en_US
dc.publisher	Future Science OA	en_US
dc.subject	Buruli ulcer	en_US
dc.subject	environmental pathogen	en_US
dc.subject	mycobacteria	en_US
dc.title	Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors	en_US
dc.type	Article	en_US

Files

Now showing 1 - 1 of 1

Now showing 1 - 1 of 1