Evaluation of the fluorescent-thin layer chromatography (f-TLC) for the diagnosis of Buruli ulcer disease in Ghana

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dc.contributor.authorAmewu, R.K.
dc.contributor.authorAkolgo, G.A.
dc.contributor.authorAsare, M.E.
dc.contributor.authorAbdula, Z.
dc.contributor.authorAblordey, A.S.
dc.contributor.authorAsiedu, K.
dc.date.accessioned2022-09-30T10:47:18Z
dc.date.available2022-09-30T10:47:18Z
dc.date.issued2022
dc.descriptionResearch Articleen_US
dc.description.abstractBuruli ulcer is a tissue necrosis infection caused by an environmental mycobacterium called Mycobacterium ulcerans (MU). The disease is most prevalent in rural areas with the highest rates in West and Central African countries. The bacterium produces a toxin called mycolactone which can lead to the destruction of the skin, resulting in incapacitating deformities with an enormous economic and social burden on patients and their caregivers. Even though there is an effective antibiotic treatment for BU, the control and management rely on early case detection and rapid diagnosis to avert morbidities. The diagnosis of Mycobacterium ulcerans relies on smear microscopy, culture histopathology, and PCR. Unfortunately, all the current laboratory diagnostics have various limitations and are not available in endemic communities. Consequently, there is a need for a rapid diagnostic tool for use at the community health centre level to enable diagnosis and confirmation of suspected cases for early treatment. The present study corroborated the diagnostic performance and utility of fluorescent-thin layer chromatography (f-TLC) for the diagnosis of Buruli ulcer.en_US
dc.identifier.citationCitation: Amewu RK, Akolgo GA, Asare ME, Abdulai Z, Ablordey AS, Asiedu K (2022) Evaluation of the fluorescent-thin layer chromatography (fTLC) for the diagnosis of Buruli ulcer disease in Ghana. PLoS ONE 17(8): e0270235. https://doi. org/10.1371/journal.pone.0270235en_US
dc.identifier.other| https://doi.org/10.1371/journal.pone.0270235
dc.identifier.urihttp://localhost:8080/handle/123456789/38306
dc.language.isoenen_US
dc.publisherPLOS ONEen_US
dc.subjectBuruli ulcer disease ien_US
dc.subjectfluorescent-thin layer chromatography (f-TLC)en_US
dc.subjectGhanaen_US
dc.titleEvaluation of the fluorescent-thin layer chromatography (f-TLC) for the diagnosis of Buruli ulcer disease in Ghanaen_US
dc.typeArticleen_US

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