IN VIVO: sensitivity of P. falciparum to Chloroquine in Accra, Ghana.
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Ghana Medical Journal
Abstract
The in vivo sensitivity of P. falciparum to
chloroquine was studied in an urban paediatric
hospital in Charla in 1984 and /987. 36
children were studied in 1984 and 100% parasite
clearance was obtained in 74.25 ± 25.5
hours (48 to 120 hours). mean ± SD (range),
after treatment with chloroquine 25mg base/kg
body weight total dose. 41 out of 44 children
studied in 1987 similarly had parasite clearance
in 68.5 ± 27. 7 hours (24 to 120 hours). Resistance
at the RI and RII levels were noted
in one and two of the children respectively.
The proportion of children parasitaemic at 72
hours was age related and suggest the role of
immunity in the sensitivity of P. falciparum to
chloroquine. In 1984 estimation of whole
blood chloroquine levels before treatment in
hospital indicated prior administration of the
drug before attending hospital.
Description
Journal Article on P. falciparum to Chloroquine in Accra