Human leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian children

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dc.contributor.authorYamazaki, A.
dc.contributor.authorYasunami, M.
dc.contributor.authorOfori, M.
dc.contributor.authorHorie, H.
dc.contributor.authorKikuchi, M.
dc.contributor.authorHelegbe, G.
dc.contributor.authorTakaki, A.
dc.contributor.authorIshii, K.
dc.contributor.authorOmar, A.H.
dc.contributor.authorAkanmori, B.D.
dc.contributor.authorHirayama, K.
dc.date.accessioned2019-05-09T13:49:29Z
dc.date.available2019-05-09T13:49:29Z
dc.date.issued2011-10
dc.description.abstractA prospective study that included 429 children for active detection of mild malaria was conducted in a coastal region of Ghana to reveal whether the incidence of malaria is affected by human leukocyte antigen (HLA) polymorphism. During 12 months of follow-up, 85 episodes of mild clinical malaria in 74 individuals were observed, and 34 episodes among them were accompanied with significant parasitemia at >5000 infected red blood cells per cubic millimeter. Attributable and relative risks conferred by genetic factors in the HLA region were evaluated by comparison of the incidence in children, stratified by carrier status, of a given allele of HLA-A, -B, -DRB1 and TNFA promoter polymorphism. HLA-B*35:01 reduced the incidence by 0.178 events per person per year (0.060 versus 0.239 for B*35:01-positive and -negative subpopulations, respectively), and a relative risk of 0.25, which remained statistically significant after Bonferroni's correction for multiple testing (p c = 8.2 × 10 -5). Further, HLA-B*35:01 and -B*53:01 exhibited opposite effects on the incidence of malaria with significant parasitemia. When parasite densities in different HLA carriers status were compared, HLA-A*01 conferred an increase in parasite load (p = 6.0 × 10 -7). In addition, we found a novel DRB1 allele that appears to have emerged from DRB1*03:02 by single nucleotide substitution. © 2011 American Society for Histocompatibility and Immunogenetics.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.humimm.2011.06.007
dc.identifier.otherVolume 72, Issue 10, Pages 881-888
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29902
dc.language.isoenen_US
dc.publisherHuman Immunologyen_US
dc.subjectCohort studyen_US
dc.subjectGenetic susceptibilityen_US
dc.subjectHLA haplotypeen_US
dc.subjectHLA polymorphismen_US
dc.subjectMalariaen_US
dc.subjectResistanceen_US
dc.titleHuman leukocyte antigen class I polymorphisms influence the mild clinical manifestation of Plasmodium falciparum infection in Ghanaian childrenen_US
dc.typeArticleen_US

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