Key genetic variants associated with variation of milk oligosaccharides from diverse human populations

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dc.contributor.authorWilliams, J.E.
dc.contributor.authorMcGuire, M.K.
dc.contributor.authorMeehan, C.L.
dc.contributor.authorMcGuire, M.A.
dc.contributor.authorBrooker, S.L.
dc.contributor.authorKamau-Mbuthia, E.W.
dc.contributor.authorKamundia, E.W.
dc.contributor.authorMbugua, S.
dc.contributor.authorMoore, S.E.
dc.contributor.authorPrentice, A.M.
dc.contributor.authorOtoo, G.E.
dc.contributor.authorRodríguez, J.M.
dc.contributor.authorPareja, R.G.
dc.contributor.authorFoster, J.A.
dc.contributor.authorSellen, D.W.
dc.contributor.authorKita, D.G.
dc.contributor.authorNeibergs, H.L.
dc.contributor.authorMurdoch, B.M.
dc.date.accessioned2021-12-10T11:34:05Z
dc.date.available2021-12-10T11:34:05Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractHuman milk oligosaccharides (HMO), the third most abundant component of human milk, are thought to be important contributors to infant health. Studies have provided evidence that geography, stage of lactation, and Lewis and secretor blood groups are associated with HMO profile. However, little is known about how variation across the genome may influence HMO composition among women in various populations. In this study, we performed genome-wide association analyses of 395 women from 8 countries to identify genetic regions associated with 19 different HMO. Our data support FUT2 as the most significantly associated (P < 4.23−9 to P < 4.5−70) gene with seven HMO and provide evidence of balancing selection for FUT2. Although polymorphisms in FUT3 were also associated with variation in lacto-N-fucopentaose II and difucosyllacto-N-tetrose, we found little evidence of selection on FUT3. To our knowledge, this is the first report of the use of genome-wide association analyses on HMO.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.ygeno.2021.04.004
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37229
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectHuman milken_US
dc.subjectOligosaccharidesen_US
dc.subjectGWASen_US
dc.subjectFUT2en_US
dc.subjectFUT3en_US
dc.titleKey genetic variants associated with variation of milk oligosaccharides from diverse human populationsen_US
dc.typeArticleen_US

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