Plasmodium malariae, current knowledge and future research opportunities on a neglected malaria parasite species

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dc.contributor.authorOriero, E.C.
dc.contributor.authorAmenga-Etego, L.
dc.contributor.authorIshengoma, D.S.
dc.contributor.authorAmambua-Ngwa, A.
dc.date.accessioned2022-01-17T16:43:05Z
dc.date.available2022-01-17T16:43:05Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractPlasmodium malariae is often reported as a benign malaria parasite. There are limited data on its biology and disease burden in sub-Saharan Africa (sSA) possibly due to the unavailability of specific and affordable tools for routine diagnosis and large epidemiology studies. In addition, P. malariae occurs at low parasite densities and in co-infections with other species, predominately P. falciparum. The paucity of data on P. malariae infections limits the capacity to accurately deter mine its contribution to malaria and the effect of control interventions against P. falciparum on its prevalence. Here, we summarise the current knowledge on P. malariae epidemiology in sSA - overall prevalence ranging from 0-32%, as detected by different diagnostic methods; seroprevalence ranging from 0–56% in three countries (Mozambique, Benin and Zimbabwe), and explore the future application of next-generation sequencing technologies as a tool for enriching P. malariae genomic epidemiology. This will provide insights into important adaptive mechanisms of this neglected non-falciparum species, including antimalarial drug resistance, local and regional parasite transmission patterns and genomic signatures of selection. Improved diagnosis and genomic surveillance of non-falciparum malaria parasites in Africa would be helpful in evaluating progress towards elimination of all human Plasmodium species.en_US
dc.identifier.otherhttps://doi.org/10.1080/1040841X.2020.1838440
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37671
dc.language.isoenen_US
dc.publisherTaylor & Francis Groupen_US
dc.subjectPlasmodium malariaeen_US
dc.subjectmalaria epidemiologyen_US
dc.subjecteliminationen_US
dc.subjectnon-falciparumen_US
dc.titlePlasmodium malariae, current knowledge and future research opportunities on a neglected malaria parasite speciesen_US
dc.typeArticleen_US

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