A study on the provocative day test effect of ivermectin and albendazole on nocturnal periodic wuchereria bancrofti microfilaraemia.

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Date

1999

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Publisher

Transactions of the Royal Society of Tropical Medicine and Hygiene

Abstract

We conducted a randomized double-blind placebo-controlled study, in the Ahanta West District of Ghana, on the provocative day test effect of ivermectin and albendazole alone and in combination on nocturnal periodic Wuchereria bancrofti microfilaraemia. Sixty-three individuals with high night-time microfilaria (mf) intensities were identified in 1997 or 1998 and randomized into 4 groups. Blood samples for mf were then collected from the same individuals in the daytime (between 09:00 and 15:00) immediately before and 30–50 min after treatment. Groups 1–4 were treated with ivermectin alone (150–200 μg/kg), albendazole alone (400 mg), the combination of ivermectin and albendazole, and placebo, respectively. Intensities of mf in daytime samples were considerably lower than in night-time samples. Neither ivermectin or albendazole alone nor their combination provoked significant liberation of W. bancrofti mf into the peripheral circulation after the daytime treatment.

Description

Keywords

Filariasis, Wuchereria bancrofti, Nocturnal periodicity, Provocative day test, Ivermectin, Albendazole, Diagnosis, Ghana

Citation

Dunyo, S. K., Nkrumah, F. K., & Simonsen, P. E. (1999). A study on the provocative day test effect of ivermectin and albendazole on nocturnal periodic wuchereria bancrofti microfilaraemia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(6), 608-610.