Exposure to a Slightly Sweet Lipid-Based Nutrient Supplement During Early Life Does Not Increase the Preference for or Consumption of Sweet Foods and Beverages by 4-6-y-Old Ghanaian Preschool Children: Follow-up of a Randomized Controlled Trial
dc.contributor.author | Okronipa, H. | |
dc.contributor.author | Arimond, M. | |
dc.contributor.author | Arnold, C.D. | |
dc.contributor.author | Young, R.R. | |
dc.contributor.author | Adu-Afarwuah, S. | |
dc.contributor.author | Tamakloe, S.M. | |
dc.contributor.author | Ocansey, M.E. | |
dc.contributor.author | Kumordzie, S.M. | |
dc.contributor.author | Oaks, B.M. | |
dc.contributor.author | Mennella, J.A. | |
dc.contributor.author | Dewey, K.G. | |
dc.date.accessioned | 2019-05-16T16:30:25Z | |
dc.date.available | 2019-05-16T16:30:25Z | |
dc.date.issued | 2019-03 | |
dc.description.abstract | Background The impact of feeding a slightly sweet nutrient supplement early in life on later sweet taste preference is unknown. Objective We tested the hypothesis that the level of sucrose most preferred by 4–6-y-old children exposed to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not be higher than that of children never exposed to LNS. Design We followed up children born to women (n = 1,320) who participated in a randomized trial in Ghana. In one group, LNS was provided to women on a daily basis during pregnancy and the first 6 mo postpartum and to their infants from age 6 to 18 mo (LNS group). The control groups received daily iron and folic acid or multiple micronutrients during pregnancy and the first 6 mo postpartum, with no infant supplementation (non-LNS group). At age 4–6 y, we randomly selected a subsample of children (n = 775) to assess the concentration of sucrose most preferred using the Monell 2-series, forced-choice, paired-comparison tracking procedure. We compared LNS with non-LNS group differences using a noninferiority margin of 5% weight/volume (wt/vol). Results Of the 624 children tested, most (61%) provided reliable responses. Among all children, the mean ± SD sucrose solution most preferred (% wt/vol) was 14.6 ± 8.6 (LNS group 14.9 ± 8.7; non-LNS group 14.2 ± 8.4). However, among children with reliable responses, it was 17.0 ± 10.2 (LNS group 17.5 ± 10.4; non-LNS group 16.5 ± 10.0). The upper level of the 95% CI of the difference between groups did not exceed the noninferiority margin in either the full sample or those with reliable responses, indicating that the LNS group did not have a higher sweet preference than the non-LNS group. Conclusion Exposure to a slightly sweet nutrient supplement early in life did not increase the level of sweet taste most preferred during childhood. This trial was registered at clinicaltrials.gov as NCT00970866. | en_US |
dc.identifier.other | DOI: 10.1093/ajcn/nqy352 | |
dc.identifier.other | Vol.109(4): pp 1224-1232 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/30095 | |
dc.language.iso | en | en_US |
dc.publisher | American Journal of Clinical Nutrition | en_US |
dc.subject | Lipid-based nutrient supplements | en_US |
dc.subject | Sweet taste preference | en_US |
dc.subject | Monell forced-choice test | en_US |
dc.subject | Children | en_US |
dc.subject | Ghana | en_US |
dc.title | Exposure to a Slightly Sweet Lipid-Based Nutrient Supplement During Early Life Does Not Increase the Preference for or Consumption of Sweet Foods and Beverages by 4-6-y-Old Ghanaian Preschool Children: Follow-up of a Randomized Controlled Trial | en_US |
dc.type | Article | en_US |
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