Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

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dc.contributor.authorTiendrebeogo, R.W.
dc.contributor.authorAdu, B.
dc.contributor.authorSingh, S.K.
dc.contributor.authorDziegiel, M.H.
dc.contributor.authorNébié, I.
dc.contributor.authorSirima, S.B.
dc.contributor.authorChristiansen, M.
dc.contributor.authorDodoo, D.
dc.contributor.authorTheisen, M.
dc.date.accessioned2018-11-15T08:27:26Z
dc.date.available2018-11-15T08:27:26Z
dc.date.issued2015-03
dc.description.abstractThe antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America.en_US
dc.identifier.otherDOI: 10.1093/ofid/ofv044
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/25523
dc.language.isoenen_US
dc.publisherOpen Forum Infectious Diseasesen_US
dc.subjectantibody-dependent cellular inhibitionen_US
dc.subjectChildrenen_US
dc.subjectLongitudinal cohort studyen_US
dc.subjectMalariaen_US
dc.subjectMonocytesen_US
dc.subjectPlasmodium falciparumen_US
dc.titleAntibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian childrenen_US
dc.typeArticleen_US

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