Biomarker of Anopheles exposure in Ghanaian children with hemoglobin S and C

Simple item page
dc.contributor.authorLondono-Renteria, B.
dc.contributor.authorSeidu, Z.
dc.contributor.authorLamptey, H.
dc.contributor.authorOfori, M.F.
dc.contributor.authorHviid, L.
dc.contributor.authorLopez-Perez, M.
dc.date.accessioned2023-12-07T09:52:32Z
dc.date.available2023-12-07T09:52:32Z
dc.date.issued2024
dc.descriptionResearch Articleen_US
dc.description.abstractHeterozygous carriers of hemoglobin S and C (HbAS and HbAC) have a reduced risk of severe malaria but are not protected from Plasmodium falciparum infection, suggesting that the protection involves acquired immunity. During a blood meal, female Anopheles mosquitoes inject saliva that can elicit a host antibody response, which can serve as a proxy for exposure to Plasmodium infection. Previous studies have shown that the peptide gSG6-P1 of An. gambiae saliva is antigenic and highly Anopheles specific. Here, we used plasma samples from 201 Gha naian children with wild-type hemoglobin (HbAA), HbAS, and HbAC to evaluate antibody levels against gSG6-P1 as a serological biomarker of Anopheles exposure and, therefore of P. falciparum infection risk. Malaria antigen (PfCSP, GLURP, Pfs230, and HB3VAR06)-specific IgG levels, demographic data, and data regarding P. falciparum infection and malaria control practices were also analyzed. Children with active P. falciparum infection had higher antibody levels against all antigens, and those with HbAS and HbAC had significantly higher antibody levels against Pfs230. Pfs230-specific IgG correlated negatively with gSG6-P1-specific IgG in children with HbAC. Our results highlight the importance of studying the role of hemoglobinopathies in malaria transmission to improve control interventions.en_US
dc.identifier.otherhttps://doi.org/10.1016/j.actatropica.2023.107043
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/40849
dc.language.isoenen_US
dc.publisherActa Tropicaen_US
dc.subjectAntibody responseen_US
dc.subjectAnophelesen_US
dc.subjectGhanaen_US
dc.titleBiomarker of Anopheles exposure in Ghanaian children with hemoglobin S and Cen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Biomarker of Anopheles exposure in Ghanaian children with hemoglobin S.pdf
Size:
1.35 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Immunology Department