Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia
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Date
2020-04-03
Journal Title
Journal ISSN
Volume Title
Publisher
BMC Psychiatry
Abstract
Background: Diabetes often occurs together with tuberculosis (TB) and both may affect each other negatively.
Diabetes may be associated with neurocognitive dysfunctioning in affected patients and may negatively impact
treatment adherence and outcomes. This study compared the neurocognitive status between newly diagnosed
smear positive tuberculosis patients with dysglycaemia and those with normoglycaemia.
Methods: The current study was a cross-sectional study involving one hundred and forty-six (146) newly diagnosed
smear positive TB patients. Oral glucose tolerance test (OGTT) was performed and the results were categorized as
either normoglycaemia, impaired glucose tolerance (IGT), impaired fasting glucose (IFG) or diabetes.
Neurocognitive functioning among study participants was assessed at the time of TB diagnosis using Cognitive
Failure Questionnaire (CFQ), Montreal Cognitive Assessment tool (MoCA), California Verbal Learning Test (CVLT), Brief
Symptom Inventory (BSI) and the Spitzer Quality of Life Index (QLI).
Results: The mean age of the participants (n = 146) was 38.7 years with 78.8% being males and 21.2% females.
Using the fasting blood glucose test, the prevalence of impaired fasting glucose and diabetes were 5.5 and 3.4%
respectively, both representing a total of 13 out of the 146 participants; whilst the prevalence of impaired glucose
tolerance and diabetes using 2-h post-glucose values were 28.8 and 11.6% respectively, both representing a total of
59 out of the 146 participants.
There were no significant differences in the mean scores on the neurocognitive measures between the
dysglaycaemia and normoglycamic groups using fasting plasma glucose (FPG). However, there were significant
differences in the mean scores between the dysglycaemia and normal groups using 2-h postprandial (2HPP)
glucose values on Phobic Anxiety (Normal, Mean = 0.38 ± 0.603; dysglycaemia, Mean = 0.23 ± 0.356; p = 0.045), and
Montreal Cognitive Assessment (MoCA) scores (17.26 ± 5.981 vs. 15.04 ± 5.834, p = 0.037).
Conclusion: Newly diagnosed smear positive patients with dysglycaemia were associated with significantly lower
mean cognitive scores and scores on phobic anxiety than those with normoglyacaemia. The latter finding must be
further explored.
Description
Research Article
Keywords
Tuberculosis, Smear positive, Dysglycaemia, Neuropsychological disorders, Diabetes, neurocognitive dysfunctioning
Citation
AMA Yorke E, Boima V, Dey ID, et al. Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia. BMC Psychiatry. 2020;20(1):143. Published 2020 Apr 3. doi:10.1186/s12888-020-02570-8 MLA Yorke, Ernest et al. “Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia.” BMC psychiatry vol. 20,1 143. 3 Apr. 2020, doi:10.1186/s12888-020-02570-8 APA Yorke, E., Boima, V., Dey, I. D., Ganu, V., Nkornu, N., Acquaye, K. S., & Mate-Kole, C. C. (2020). Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia. BMC psychiatry, 20(1), 143. https://doi.org/10.1186/s12888-020-02570-8 NLM Yorke E, Boima V, Dey ID, Ganu V, Nkornu N, Acquaye KS, Mate-Kole CC. Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia. BMC Psychiatry. 2020 Apr 3;20(1):143. doi: 10.1186/s12888-020-02570-8. PMID: 32245444; PMCID: PMC7119271.