Hydroxyapatite Nano-Pillars On TI-6Al-4V: Enhancements In Cell Spreading And Proliferation During Cell/Surface Integration

Abstract

Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti-6Al-4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of bio medical devices into the human body. This paper presents a novel, easy and repro ducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti 6Al-4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scanning electron microscopy equipped with energy dispersive x-ray spectroscopy. The nanostructured/nanoscale coatings are shown to enhance the early stages of cell spreading and integration of bone cells (hFOB cells) on Ti-6Al-4V surfaces. The improvements include the acceleration of extra-cellular matrix, cell spreading and proliferation by nanoscale HA structures on the coated surfaces. The implications of the results are discussed for the develop ment of HA nanostructures for the improved osseointegration of Ti-6Al-4V in ortho pedic and dental applications.