Humoral immune response to Epstein-Barr virus antigens and immunoglobulin allotypes in African Burkitt lymphoma patients.

dc.contributor.authorBiggar, R.J.
dc.contributor.authorPandey, J.P.
dc.contributor.authorHenle, W.
dc.contributor.authorNkrumah, F.K.
dc.contributor.authorLevine, P.H.
dc.date.accessioned2013-06-12T11:35:08Z
dc.date.accessioned2017-10-16T12:58:03Z
dc.date.available2013-06-12T11:35:08Z
dc.date.available2017-10-16T12:58:03Z
dc.date.issued1984
dc.description.abstractWe examined whether any immunoglobulin allotype was associated with an elevated risk of Burkitt's lymphoma because of the association between Burkitt's lymphoma and abnormalities of the immunoglobulin-bearing chromosomes. The distribution of Gm and Km phenotypes among 56 Burkitt lymphoma cases and 25 age-matched controls was unremarkable. Burkitt's lymphoma has also been associated with the Epstein-Barr virus, and we therefore sought a relationship between immunoglobulin allotypes and antibody response to the component antigens of the Epstein-Barr virus, VCA, EA-D, EA-R and EBNA. No immunoglobulin phenotype was associated with higher antibody titers against any antigen, but there appeared to be an interactive effect in which persons homozygous at both Gm and Km loci had elevated titers against several of the component antigens of the Epstein-Barr virus. This is the first report of an interactive effect between immunoglobulin allotypes and viruses. Antibody titers against antigens of the Epstein-Barr virus were higher in cases than in controls, as expected. However, female cases had significantly higher titers than male cases, a finding similar to that previously reported in healthy persons.en_US
dc.identifier.citationBiggar, R. J., Pandey, J. P., Henle, W., Nkrumah, F. K., & Levine, P. H. (1984). Humoral immune response to epstein-barr virus antigens and immunoglobulin allotypes in African burkitt lymphoma patients. International Journal of Cancer, 33(5), 577-580.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/3087
dc.language.isoenen_US
dc.publisherInternational Journal of Canceren_US
dc.subjectAntibody formationen_US
dc.subjectAntigensen_US
dc.subjectBurkitt's lymphomaen_US
dc.subjectFemaleen_US
dc.subjectHerpes virus 4en_US
dc.subjectHumansen_US
dc.subjectImmunoglobulin allotypesen_US
dc.subjectMaleen_US
dc.subjectPhenotypeen_US
dc.subjectSex factorsen_US
dc.titleHumoral immune response to Epstein-Barr virus antigens and immunoglobulin allotypes in African Burkitt lymphoma patients.en_US
dc.typeArticleen_US

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