ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children

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dc.contributor.authorSuurbaar, J.
dc.contributor.authorMoussiliou, A.
dc.contributor.authorTahar, R.
dc.contributor.authorOlsen, R.W.
dc.contributor.authorAdams, Y.
dc.contributor.authorDalgaard, N.
dc.contributor.authorBaafour, E.K.
dc.contributor.authorAdukpo, S.
dc.contributor.authorHviid, L.
dc.contributor.authorKusi, K.A.
dc.contributor.authorAlao, J.
dc.contributor.authorOfori, M.F.
dc.date.accessioned2022-08-16T14:39:42Z
dc.date.available2022-08-16T14:39:42Z
dc.date.issued2022-12
dc.descriptionResearch Articleen_US
dc.description.abstractMembers of the highly polymorphic Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on the surface of infected erythrocytes (IEs) are important virulence factors, which mediate vascular adhesion of IEs via endothelial host receptors and are targets of naturally acquired immunity. The PfEMP1 family can be divided into clinically relevant subgroups, of which some bind intercellular adhesion molecule 1 (ICAM-1). While the acquisition of IgG specific for ICAM-1-binding DBLβ domains is known to differ between PfEMP1 groups, its ability to induce antibody-dependent cellular phagocytosis (ADCP) is unclear. We therefore measured plasma levels of DBLβ-specific IgG, the ability of such IgG to inhibit PfEMP1-binding to ICAM-1, and its ability to opsonize IEs for ADCP, using plasma from Beninese children with severe (SM) or uncomplicated malaria (UM). IgG specific for DBLβ from group A and B ICAM-1-binding PfEMP1 were dominated by IgG1 and IgG3, and were similar in SM and UM. However, levels of plasma IgG inhibiting ICAM-1-binding of group A DBLβ of PFD1235w was significantly higher in children with UM than SM, and acute UM plasma induced a higher ADCP response than acute SM plasma.en_US
dc.identifier.issn20452322
dc.identifier.otherhttps://doi.org/10.1038/s41598-022-16305-0
dc.identifier.urihttp://localhost:8080/handle/123456789/38243
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.subjectAntibodiesen_US
dc.subjectProtozoanen_US
dc.subjectAntigensen_US
dc.subjectProtozoanen_US
dc.subjectChilden_US
dc.subjectErythrocytesen_US
dc.subjectHumansen_US
dc.subjectImmunoglobulin Gen_US
dc.subjectIntercellular Adhesion Molecule-1en_US
dc.subjectMalariaen_US
dc.subjectFalciparumen_US
dc.subjectPhagocytosisen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectProtozoan Proteinsen_US
dc.titleICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese childrenen_US
dc.typeArticleen_US

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