Methionine Metabolism in Filarial Worms

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dc.contributor.advisorOduro, K.K.
dc.contributor.advisorJaffe, J.J.
dc.contributor.advisorGyang, F.N.
dc.contributor.authorAcquaah, R.A.
dc.contributor.otherUniversity of Ghana, College of Basic and Applied Sciences, School of Biological Sciences, Department of Biochemistry, Cell and Molecular Biology
dc.date.accessioned2015-06-23T15:35:43Z
dc.date.accessioned2017-10-13T15:25:30Z
dc.date.available2015-06-23T15:35:43Z
dc.date.available2017-10-13T15:25:30Z
dc.date.issued1980-09
dc.description.abstractAdult filariae apparently lack the vitamin BI2-dependent and -independent methyltransferases for the de novo synthesis of methionine and seem to meet their requirement of this amino acid from an exogenous source and the activity of S-adenosylmethionine(AdoMet):homocysteine S-methyltransferase The properties of filarial AdoMet:homocysteine methyl transferase were similar to the analogous microbial enzyme. However, adult filariae possess the enzymatic capability to metabolize methionine to cyst(e)ine. When incubated in the presence of L-{CH3-14C} methionine to induce them to synthesise AdoMet, adult Dirofilaria immitis incorporated the radiolabel into phospholipid and protein fractions. The significance of filarial methionine metabolism especially with regard to its suitability as a potential target for antifilarial chemotherapy is discussed.en_US
dc.format.extentx,102p
dc.identifier.issn30692107854166
dc.identifier.urihttp://197.255.68.203/handle/123456789/6269
dc.language.isoen_USen_US
dc.publisherUniversity of Ghanaen_US
dc.rights.holderUniversity of Ghana
dc.titleMethionine Metabolism in Filarial Wormsen_US
dc.typeThesisen_US

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