Dichapetalin M from Dichapetalum madagascariense

Abstract

The roots of Dichapetalum madagascariensis have yielded the new dichapetalin M, together with the previously reported dichapetalin A. This brings to nine, the total number of dichapetalins so far isolated from the roots of the plant, and to thirteen, the total number of dichapetalins isolated from the Dichapetalaceae. Dichapetalin M exhibited greater toxicity towards brine shrimp larvae than dichapetalin A, which has demonstrated cell inhibition against various cancer cell lines.