Antitumor agents. 250. design and synthesis of new curcumin analogues as potential anti-prostate cancer agents

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dc.contributor.authorLin, L.
dc.contributor.authorShi, Q.
dc.contributor.authorNyarko, A.K.
dc.contributor.authorBastow, K.F.
dc.contributor.authorWu, C.
dc.contributor.authorSu, C.
dc.contributor.authorLee, K.
dc.date.accessioned2013-06-16T09:44:28Z
dc.date.accessioned2017-10-16T13:02:49Z
dc.date.available2013-06-16T09:44:28Z
dc.date.available2017-10-16T13:02:49Z
dc.date.issued2006
dc.description.abstractIn a continuing study of curcumin analogs as potential drug candidates to treat prostate cancer at both androgen-dependent and androgen-refractory stages, we designed and synthesized over 40 new analogs classified into four series: monophenyl analogs (series A), heterocycle-containing analogs (series B), analogs bearing various substituents on the phenyl rings (series C) and analogs with various linkers (series D). These new compounds were tested for cytotoxicity against two human prostate cancer cell lines, androgen-dependent LNCaP and androgen-independent PC-3. Antiandrogenic activity was also evaluated in LNCaP cells and PC-3 cells transfected with wild-type androgen receptor. Ten compounds possessed potent cytotoxicity against both LNCaP and PC-3 cells; seven only against LNCaP; and one solely against PC-3. This study established an advanced structure-activity relationship (SAR), and these correlations will guide the further design of new curcumin analogs with better anti-prostate cancer activity.en_US
dc.identifier.citationLin, L., Shi, Q., Nyarko, A.K., Bastow, K. F., Wu, C.., Su, C., Lee, K. -. (2006). Antitumor agents. 250. design and synthesis of new curcumin analogues as potential anti-prostate cancer agents. Journal of Medicinal Chemistry, 49(13), 3963-3972.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/3223
dc.language.isoenen_US
dc.publisherJournal of Medicinal Chemistryen_US
dc.titleAntitumor agents. 250. design and synthesis of new curcumin analogues as potential anti-prostate cancer agentsen_US
dc.typeArticleen_US

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