Haptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV-infected patients on highly active antiretroviral therapy

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dc.contributor.authorTagoe, E.A.
dc.contributor.authorTagoe, I.N.A.
dc.contributor.authorKuleape, J.A.
dc.contributor.authorPuplampu, P.
dc.contributor.authorAmanquah, S.
dc.contributor.authorAsare-Anane, H.
dc.contributor.authorQuaye, O.
dc.date.accessioned2019-06-06T11:02:49Z
dc.date.available2019-06-06T11:02:49Z
dc.date.issued2019-03
dc.description.abstractOBJECTIVE: Highly active antiretroviral therapy (HAART) has considerably reduced HIV/AIDS-related morbidity and mortality; however, the therapy has been associated with the development of cardiovascular disease (CVD), and genetic predisposition factors may aggravate disease outcome. This study was aimed at investigating the relationship between haptoglobin phenotypes and risk factors of CVD in HIV patients. METHODS: A total of 105 HIV sero-positive patients on HAART and 75 HIV-infected HAART-naïve individuals were enrolled in the study. Socio-demographics and clinical characteristics of the participants were obtained using a well-structured questionnaire. Lipid profile, lactate dehydrogenase (LDH) and haptoglobin (Hp) phenotypes were analysed from serum whiles haemoglobin (Hb) level, CD4+ cell count and HIV viral RNA load were determined using whole blood. RESULTS: Atherogenic index of plasma (AIP) was significantly higher in patients on HAART than the naïve group (P < 0.05). Age, BMI, visceral fat, systolic blood pressure LDH and lipid variables strongly and positively correlated with AIP (P < 0.05), with the exception of HDL-c (P < 0.001) which showed a negative correlation. HAART was associated with hypertension (χ2 = 4.33, P = 0.037), hypercholesterolaemia (χ2 = 10.99, P < 0.001), elevated LDL-c (χ2 = 10.30, P < 0.001) and decreased HDL-c (χ2 = 3.87, P = 0.09). Hp2-2 and Hp0 collectively was strongly associated with hypertension (OR = 2.54, P = 0.011), obesity (OR = 5.97, P < 0.001) and hypercholesterolaemia (OR = 2.99, P < 0.001). CONCLUSION: HIV/AIDS patients on HAART expressing Hp phenotypes with weak antioxidant capacity have an increased risk of developing CVD.en_US
dc.identifier.otherhttps://doi.org/10.1111/tmi.13229
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30519
dc.language.isoenen_US
dc.publisherTropical Medicine and International Healthen_US
dc.subjectHaptoglobin phenotypesen_US
dc.subjectHIVen_US
dc.subjectHighly active antiretroviral therapyen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectAntioxidanten_US
dc.titleHaptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV-infected patients on highly active antiretroviral therapyen_US
dc.typeArticleen_US

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