Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate
dc.contributor.author | Rateb, M.E. | |
dc.contributor.author | Zhai, Y. | |
dc.contributor.author | Ehrner, E. | |
dc.contributor.author | Rath, C.M. | |
dc.contributor.author | Wang, X. | |
dc.contributor.author | Tabudravu, J. | |
dc.contributor.author | Ebel, R. | |
dc.contributor.author | Bibb, M. | |
dc.contributor.author | Kyeremeh, K. | |
dc.contributor.author | Dorrestein, P.C. | |
dc.contributor.author | Hong, K. | |
dc.contributor.author | Jaspars, M. | |
dc.contributor.author | Deng, H. | |
dc.date.accessioned | 2018-09-13T10:50:35Z | |
dc.date.available | 2018-09-13T10:50:35Z | |
dc.date.issued | 2015-10 | |
dc.description.abstract | Linaridins are rare linear ribosomally-synthesized and post-translationally modified peptides (RiPPs) and only two, cypemycin and SGR-1832, in this family have been identified so far. Legonaridin 1 has been discovered as a new member of linaridins through chemical isolation, peptidogenomics, comprehensive 1- and 2-D NMR and advanced Marfey's analyses from the soil bacterium Streptomyces sp. CT34, an isolate collected from Legon, Ghana. Bioinformatics analysis of the gene cluster suggested that the biosynthesis of legonaridin 1 is different from those of cypemycin and SGR-1832. Consistent with bioinformatics and peptidogenomics analyses, 1 has a total of nine post-modifications, 8 dehydrobutyrine residues and a N,N-dimethylated N-terminus with a carboxylic acid at the C-terminus. Legonaridin 1 is structurally different from the two known linaridins comprising a new subfamily. This is the first time that NMR spectroscopy is used to establish the 2-D structure of a linaridin RiPP. | en_US |
dc.identifier.other | doi: 10.1039/c5ob01269d | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/24127 | |
dc.language.iso | en | en_US |
dc.publisher | Organic and Biomolecular Chemistry | en_US |
dc.subject | Legonaridin | en_US |
dc.subject | linaridin | en_US |
dc.subject | Streptomyces | en_US |
dc.subject | Ghana | en_US |
dc.subject | ribosomally-synthesized and post-translationally modified peptides (RiPPs) | en_US |
dc.subject | peptidogenomics | en_US |
dc.subject | dehydrobutyrine residues | en_US |
dc.title | Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate | en_US |
dc.type | Article | en_US |
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