Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate

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dc.contributor.authorRateb, M.E.
dc.contributor.authorZhai, Y.
dc.contributor.authorEhrner, E.
dc.contributor.authorRath, C.M.
dc.contributor.authorWang, X.
dc.contributor.authorTabudravu, J.
dc.contributor.authorEbel, R.
dc.contributor.authorBibb, M.
dc.contributor.authorKyeremeh, K.
dc.contributor.authorDorrestein, P.C.
dc.contributor.authorHong, K.
dc.contributor.authorJaspars, M.
dc.contributor.authorDeng, H.
dc.date.accessioned2018-09-13T10:50:35Z
dc.date.available2018-09-13T10:50:35Z
dc.date.issued2015-10
dc.description.abstractLinaridins are rare linear ribosomally-synthesized and post-translationally modified peptides (RiPPs) and only two, cypemycin and SGR-1832, in this family have been identified so far. Legonaridin 1 has been discovered as a new member of linaridins through chemical isolation, peptidogenomics, comprehensive 1- and 2-D NMR and advanced Marfey's analyses from the soil bacterium Streptomyces sp. CT34, an isolate collected from Legon, Ghana. Bioinformatics analysis of the gene cluster suggested that the biosynthesis of legonaridin 1 is different from those of cypemycin and SGR-1832. Consistent with bioinformatics and peptidogenomics analyses, 1 has a total of nine post-modifications, 8 dehydrobutyrine residues and a N,N-dimethylated N-terminus with a carboxylic acid at the C-terminus. Legonaridin 1 is structurally different from the two known linaridins comprising a new subfamily. This is the first time that NMR spectroscopy is used to establish the 2-D structure of a linaridin RiPP.en_US
dc.identifier.otherdoi: 10.1039/c5ob01269d
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/24127
dc.language.isoenen_US
dc.publisherOrganic and Biomolecular Chemistryen_US
dc.subjectLegonaridinen_US
dc.subjectlinaridinen_US
dc.subjectStreptomycesen_US
dc.subjectGhanaen_US
dc.subjectribosomally-synthesized and post-translationally modified peptides (RiPPs)en_US
dc.subjectpeptidogenomicsen_US
dc.subjectdehydrobutyrine residuesen_US
dc.titleLegonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolateen_US
dc.typeArticleen_US

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