Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
The Journal of Infectious Diseases
Abstract
The endothelial protein C receptor (EPCR)–rs867186 G allele has
been linked to high plasma levels of soluble EPCR (sEPCR) and
controversially associated with either susceptibility or resistance
to severe and cerebral malaria. In this study, quantitative
enzyme-linked immunosorbent assay and sequencing were
used to assess sEPCR levels and EPCR-rs867186 polymorphism
in blood samples from Beninese children with different clinical
presentations of malaria. Our findings show that sEPCR levels
were higher at hospital admission than during convalescence
and that EPCR-rs867186 G allele was associated with increased
sEPCR plasma levels, malaria severity, and mortality rate (P<
.001, P =.03, and P=.04, respectively), suggesting a role of
sEPCR in the pathogenesis of severe malaria.
Description
Research Article
Keywords
EPCR, cerebral malaria, polymorphism