Interpreting rapid diagnostic test (RDT) for Plasmodium falciparum

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dc.contributor.authorOrish, V.N.
dc.contributor.authorDe-Gaulle, V.F.
dc.contributor.authorSanyaolu, A.O.
dc.date.accessioned2019-06-13T11:52:18Z
dc.date.available2019-06-13T11:52:18Z
dc.date.issued2018-12
dc.description.abstractObjective Rapid diagnostic tests have been of tremendous help in malaria control in endemic areas, helping in diagnosis and treatment of malaria cases. It is heavily relied upon in many endemic areas where microscopy cannot be obtained. However, caution should be taken in the interpretation of its result in clinical setting due to its limitations and inherent weakness. This paper seeks to present the varying malaria RDT test results, the possible interpretations and explanation of these results common in endemic regions. Published works on malaria RDT studies were identified using the following search terms “malaria RDT in endemic areas”, “Plasmodium falciparum and bacterial coinfection” “Plasmodium falciparum RDT test results in children in endemic areas” in Google Scholar and PubMed. Results The review results show that RDT positive results in febrile patients can either be true or false positive. True positive, representing either a possible single infection of Plasmodium or a co-infection of bacteria and P. falciparum. False RDT negative results can be seen in febrile patient with P. falciparum infection in prozone effect, Histidine rich protein 2 (HRP2) gene deletion and faulty RDT kits. Hence, a scale up of laboratory facilities especially expert microscopy and other diagnostic tools is imperative.en_US
dc.identifier.otherhttps://doi.org/10.1186/s13104-018-3967-4
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30754
dc.language.isoenen_US
dc.publisherBMC Research Notesen_US
dc.subjectRapid diagnostic tests (RDT)en_US
dc.subjectMalaria diagnosisen_US
dc.subjectPlasmodium falciparum histidine rich proteins-2 (HRP2)en_US
dc.subjectParasite lactose dehydrogenase enzyme (pLDH)en_US
dc.titleInterpreting rapid diagnostic test (RDT) for Plasmodium falciparumen_US
dc.typeArticleen_US

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