A STAT6 intronic single-nucleotide polymorphism is associated with clinical malaria in Ghanaian children

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dc.contributor.authorAmoako-Sakyi, D.
dc.contributor.authorAdukpo, S.
dc.contributor.authorKusi, K.A.
dc.contributor.authorDodoo, D.
dc.contributor.authorOfori, M.F.
dc.contributor.authorAdjei, G.O.
dc.contributor.authorEdoh, D.E.
dc.contributor.authorAsmah, R.H.
dc.contributor.authorBrown, C.
dc.contributor.authorAdu, B.
dc.contributor.authorObiri-Yeboah, D.
dc.contributor.authorFutagbi, G.
dc.contributor.authorAbubakari, S.B.
dc.contributor.authorTroye-Blomberg, M.
dc.contributor.authorAkanmori, B.D.
dc.contributor.authorGoka, B.Q.
dc.contributor.authorArko-Mensah, J.
dc.contributor.authorGyan, B.A.
dc.date.accessioned2019-04-15T11:12:12Z
dc.date.available2019-04-15T11:12:12Z
dc.date.issued2016
dc.descriptionMalaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP). Compared with healthy controls, heterozygosity protected against clinical malaria: uncomplicated malaria (odds ratios [OR] = 0.13, P < 0.001), severe malarial anemia (OR = 0.18, P < 0.001), and cerebral malaria (OR = 0.39, P = 0.022). Levels of total IgE significantly differed among malaria phenotypes (P = 0.044) and rs3024974 genotypes (P = 0.037). Neither cytokine levels nor IL-6/IL-10 ratios were associated with malaria phenotypes or rs3024974 genotypes. This study suggests a role for rs3024974 in malaria pathogenesis and offers further insights into an IL-4/STAT6 pathway mutation in malaria pathogenesis. � the authors, publisher and licensee Libertas Academica Limited.en_US
dc.identifier.citationAmoako-sakyi et al. A stAt6 intronic single-nucleotide polymorphism is Associated with clinical Malaria in Ghanaian children. Genetics & Epigenetics 2016:8 7–14en_US
dc.identifier.issn1179237X
dc.identifier.otherdoi.10.4137/GeG.s38307
dc.identifier.othervol.1.8
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29214
dc.language.isoenen_US
dc.publisherLibertas Academica Ltden_US
dc.subjectGhanaen_US
dc.subjectIgEen_US
dc.subjectIntronen_US
dc.subjectMalariaen_US
dc.subjectRs3024974en_US
dc.subjectSNPen_US
dc.subjectSTAT6en_US
dc.titleA STAT6 intronic single-nucleotide polymorphism is associated with clinical malaria in Ghanaian childrenen_US
dc.typeArticleen_US

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